Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Proteome Res. 2008 Nov;7(11):4638-50. doi: 10.1021/pr800121b. Epub 2008 Sep 4.

2D difference gel electrophoresis of prepubertal and pubertal rat mammary gland proteomes.

Author information

  • 1Departments of Pharmacology & Toxicology, the UAB Center for Nutrient-Gene Interaction, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. Helenkim@uab.edu

Abstract

Rat mammary gland proteomes at day 21 (prepubertal) and day 50 (late puberty) were compared by 2D difference gel electrophoresis. Two-hundred fifty-one spots were significantly different ( p < 0.05) in abundance. Peptide mass fingerprint analysis of a subset of these proteins identified two significantly over-represented classes including structural and blood proteins (increased), and metabolism-relevant proteins (reduced) in day 50 relative to day 21 glands. This is a first report of mammary gland proteome differences at these important breast cancer-relevant time-points.

PMID:
18767877
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Write to the Help Desk