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Sci Signal. 2008 Sep 2;1(35):ra1. doi: 10.1126/scisignal.1159945.

The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development.

Author information

  • 1Endocrine Research Unit, Department of Veterans Affairs Medical Center, Department of Medicine, University of California, San Francisco, CA 94121, USA. wenhan.chang@ucsf.edu

Abstract

The extracellular Ca(2+)-sensing receptor (CaSR) plays a nonredundant role in the functions of the parathyroid gland (PTG) and the kidney. Severe hyperparathyroidism, premature death, and incomplete gene excision in Casr(-/-) mice have precluded the assessment of CaSR function in other tissues. We generated mice with tissue-specific deletion of Casr in the PTG, bone, or cartilage. Deletion of Casr in the PTG or bone resulted in profound bone defects, whereas deletion of Casr in chondrocytes (cartilage-producing cells) resulted in death before embryonic day 13 (E13). Mice in which chondrocyte-specific deletion of Casr was induced between E16 and E18 were viable but showed delayed growth plate development. Our data show a critical role for the CaSR in early embryogenesis and skeletal development.

Comment in

PMID:
18765830
[PubMed - indexed for MEDLINE]
PMCID:
PMC3538864
Free PMC Article

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