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Clin Neurophysiol. 2008 Oct;119(10):2201-4. doi: 10.1016/j.clinph.2008.07.212. Epub 2008 Aug 31.

K-complex-induced seizures in autosomal dominant nocturnal frontal lobe epilepsy.

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  • 1AP-HP, Epileptology Unit, Neurology 1 Department, La Pitié-Salpêtrière Hospital, Paris, France.



To examine in detail the relations between seizures and K-complexes in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE).


Prolonged continuous video-EEG recording and analysis of 30 seizures in an 18-year-old woman suffering from ADNFLE with a CHRNA4 gene mutation.


Twenty-seven of 30 recorded seizures started just after a K-complex. In nine cases a sound induced a K-complex that was immediately followed by the seizure. Most seizures preceded repetitive and brief ictal restarts.


Three new characteristics have been observed in this ADNFLE patient: a K-complex is almost invariably present at seizure onset; sounds trigger some seizures; ictal restarts occur often.


These new observations--the presence of K-complexes at seizure onset and occurrence of sound-triggered seizures--support the view that ADNFLE seizures may be initiated by K-complexes.

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