Cloning of a human gene encoding the general trans...[Nature. 1991]

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1: Nature. 1991 Aug 22;352(6337):689-95. Links

Cloning of a human gene encoding the general transcription initiation factor IIB.

Ha I, Lane WS, Reinberg D.

Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854-5635.

Transcription factor IIB (TFIIB) has a central role in transcription of class II genes. The purification of the human TFIIB protein and isolation of a complementary DNA encoding TFIIB activity is reported here. The sequence of TFIIB, which seems to be encoded by a single gene, contains a repeated motif, in addition to a motif with similarity to the prokaryotic sigma-factors. The recombinant protein expressed in bacteria substituted for all the functions attributed to the human TFIIB protein.

PMID: 1876184 [PubMed - indexed for MEDLINE]

Sequence of general transcription factor TFIIB and relationships to other initiation factors.
Proc Natl Acad Sci U S A. 1991 Nov 1; 88(21):9553-7.

[Proc Natl Acad Sci U S A. 1991]
Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high-mobility-group protein 2-related domains.
Proc Natl Acad Sci U S A. 1995 Jul 18; 92(15):7026-30.

[Proc Natl Acad Sci U S A. 1995]
Isolation and characterization of a cDNA encoding Drosophila transcription factor TFIIB.
Proc Natl Acad Sci U S A. 1992 Apr 1; 89(7):2839-43.

[Proc Natl Acad Sci U S A. 1992]
ReviewX-ray crystallographic studies of eukaryotic transcription initiation factors.
Philos Trans R Soc Lond B Biol Sci. 1996 Apr 29; 351(1339):483-9.

[Philos Trans R Soc Lond B Biol Sci. 1996]
ReviewThe TATA box binding protein.
Curr Opin Struct Biol. 1996 Feb; 6(1):69-75.

[Curr Opin Struct Biol. 1996]
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