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J Perinat Med. 2009;37(1):87-90. doi: 10.1515/JPM.2009.008.

National screening program vs. standardized neurodevelopmental follow-up.

Author information

  • 1Department of Neonatology, University Children's Hospital, Bonn, Germany. Cornelia.Graef@ukb.uni-bonn.de

Abstract

BACKGROUND:

Long-term follow-up is urgently needed to decide on the consequences of new therapies.

OBJECTIVE:

This study assesses the use of a national child development screening program for a follow-up examination of a defined patient group.

PATIENTS AND METHODS:

Neurodevelopmental outcome of 139 survivors after intrauterine laser coagulation for severe twin-twin transfusion syndrome was investigated both according to a standardized neurodevelopmental follow-up and according to the pediatricians' screening examinations.

RESULTS:

Screening and standardized tests revealed identical results in 90.6% of the cases. Using the national screening program only four out of 139 children (2.9%) with minor neurological disabilities would have been missed. For identifying mild or severe neurodevelopmental abnormalities the screening has a sensitivity of 78% and a specificity of 93%. The positive predictive value is 61% and the negative predictive value 97%.

CONCLUSIONS:

The use of already available and established follow-up programs for extended follow-up studies would considerably reduce costs, time and manpower.

PMID:
18759686
[PubMed - indexed for MEDLINE]
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