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Nature. 2008 Aug 28;454(7208):1065-71. doi: 10.1038/nature07216.

Puzzles, promises and a cure for ageing.

Author information

  • 1Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA. jvijg@aecom.yu.edu

Abstract

Recent discoveries in the science of ageing indicate that lifespan in model organisms such as yeast, nematodes, flies and mice is plastic and can be manipulated by genetic, nutritional or pharmacological intervention. A better understanding of the targets of such interventions, as well as the proximate causes of ageing-related degeneration and disease, is essential before we can evaluate if abrogation of human senescence is a realistic prospect.

PMID:
18756247
[PubMed - indexed for MEDLINE]
PMCID:
PMC2774752
Free PMC Article
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