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A preparation combining piperazine and senna was clinically tested among 31 families in which at least one member was found to be positive for enterobiasis by the customary cellophane-tape anal smear technique. The diagnostic smears were positive for 58 of those tested. Following a single dose of piperazine-senna mixture, all patients were cleared of the infestation as determined by the customary criteria for cure. In six patients in two families, reinfestation occurred in two to three months after the first administration. All were again cleared with one dose of the mixture. Side effects were insignificant and transient. One 4-year-old child vomited, but an hour later ingested a second dose without incident. The preparation was palatable and easily administered.
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