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J Natl Cancer Inst. 2008 Sep 3;100(17):1204-14. doi: 10.1093/jnci/djn267. Epub 2008 Aug 26.

Speeding up the evaluation of new agents in cancer.

Author information

  • 1Clinical Trials Unit, London, UK. mp@ctu.mrc.ac.uk

Abstract

Despite both the increase in basic biologic knowledge and the fact that many new agents have reached various stages of development during the last 10 years, the number of new treatments that have been approved for patients has not increased as expected. We propose the multi-arm, multi-stage trial design as a way to evaluate treatments faster and more efficiently than current standard trial designs. By using intermediate outcomes and testing a number of new agents (and combinations) simultaneously, the new design requires fewer patients. Three trials using this methodology are presented.

PMID:
18728279
[PubMed - indexed for MEDLINE]
PMCID:
PMC2528020
Free PMC Article

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