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Cell Mol Life Sci. 2008 Sep;65(18):2814-32. doi: 10.1007/s00018-008-8352-3.

Membrane fusion: SNAREs and regulation.

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  • 1Biochemistry Center, University Heidelberg, Im Neuenheimer Feld 345, 69120 Heidelberg, Germany.


SNARE (SNAP receptor) proteins drive intracellular membrane fusion and contribute specificity to membrane trafficking. The formation of SNAREpins between membranes is spatially and temporally controlled by a network of sequentially acting accessory components. These regulators add an additional layer of specificity, arrest SNAREpin intermediates, lower the energy required for fusion, and couple membrane fusion to triggering signals. The functional activity of some of these regulators determines the plasticity of regulated exocytosis.

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