Abstract
In a neutropenic murine model of invasive pulmonary aspergillosis, prophylaxis with single doses of liposomal amphotericin B or micafungin at >or=5 mg/kg of body weight improved animal survival and suppressed the lung fungal burden for up to 7 days after infection, demonstrating the potential utility of infrequent dosing with these antifungals.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / administration & dosage*
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Animals
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Antifungal Agents / administration & dosage*
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Aspergillus fumigatus / drug effects
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Aspergillus fumigatus / isolation & purification
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Colony Count, Microbial
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Disease Models, Animal
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Drug Administration Schedule
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Echinocandins / administration & dosage*
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Female
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Invasive Pulmonary Aspergillosis / etiology
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Invasive Pulmonary Aspergillosis / microbiology
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Invasive Pulmonary Aspergillosis / prevention & control*
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Lipopeptides / administration & dosage*
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Liposomes
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Micafungin
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Mice
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Mice, Inbred BALB C
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Neutropenia / complications
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Neutropenia / drug therapy
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Liposomes
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Amphotericin B
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Micafungin