Warning: The NCBI web site requires JavaScript to function. more...
Generate a file for use with external citation management software.
Center for Radiological Research, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA. djb3@columbia.edu
The tool most commonly used for quantitative predictions of dose/fractionation dependencies in radiotherapy is the mechanistically based linear-quadratic (LQ) model. The LQ formalism is now almost universally used for calculating radiotherapeutic isoeffect doses for different fractionation/protraction schemes. In summary, the LQ model has the following useful properties for predicting isoeffect doses: (1) it is a mechanistic, biologically based model; (2) it has sufficiently few parameters to be practical; (3) most other mechanistic models of cell killing predict the same fractionation dependencies as does the LQ model; (4) it has well-documented predictive properties for fractionation/dose-rate effects in the laboratory; and (5) it is reasonably well validated, experimentally and theoretically, up to about 10 Gy/fraction and would be reasonable for use up to about 18 Gy per fraction. To date, there is no evidence of problems when the LQ model has been applied in the clinic.
Images from this publication.See all images (5) Free text
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on