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Cell. 2008 Aug 22;134(4):566-8. doi: 10.1016/j.cell.2008.08.004.

Silencing HIV-1 In Vivo.

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  • Institute of Virology, University of Ulm, 89081 Ulm, Germany. frank.kirchhoff@uniklinik-ulm.de


RNA interference holds great promise for antiviral therapy, but delivering effective quantities of small interfering RNAs (siRNAs) into the right target cells in vivo represents a major challenge. Kumar et al. (2008) now report a technique to target siRNAs specifically to T cells to suppress viral infection in a humanized mouse model of HIV/AIDS.

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