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Autoimmun Rev. 2009 Jan;8(3):190-5. doi: 10.1016/j.autrev.2008.07.042. Epub 2008 Aug 24.

Transcriptional regulation of IL-2 in health and autoimmunity.

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  • 1Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

Abstract

The regulation of IL-2 production is central to our understanding of the immune system. Key during T cell activation, it also plays an essential role in the regulation of the immune response. This review discusses the function of recently described factors that modulate transcription and chromatin remodeling at the IL2 promoter. Also, it addresses the role of FoxP3 as a transcriptional regulator in conventional T cells and regulatory T cells, and the mechanisms whereby CD28 stabilizes IL2 transcription and translation. Finally, the alterations that prevent T cells from SLE patients from producing normal amounts of IL-2 upon stimulation are described.

PMID:
18723131
[PubMed - indexed for MEDLINE]
PMCID:
PMC2655130
Free PMC Article

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