Discovery of a novel class of PPARdelta... [Bioorg Med Chem Lett. 2008] - PubMed

Save items

loading

Related citations in PubMed

Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists. [Bioorg Med Chem Lett. 2011]
Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists.
Luckhurst CA, Stein LA, Furber M, Webb N, Ratcliffe MJ, Allenby G, Botterell S, Tomlinson W, Martin B, Walding A. Bioorg Med Chem Lett. 2011 Jan 1; 21(1):492-6. Epub 2010 Oct 27.
Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists. [Bioorg Med Chem Lett. 2009]
Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.
Zhang R, Deangelis A, Wang A, Sieber-McMaster E, Li X, Russell R, Pelton P, Xu J, Zhu P, Zhou L, et al. Bioorg Med Chem Lett. 2009 Feb 15; 19(4):1101-4. Epub 2009 Jan 8.
Review [Design and synthesis of peroxisome proliferator-activated receptor (PPAR) delta agonists and its implication to the driving force to elicit PPAR delta selectivity]. [Yakugaku Zasshi. 2009]
Review [Design and synthesis of peroxisome proliferator-activated receptor (PPAR) delta agonists and its implication to the driving force to elicit PPAR delta selectivity].
Kasuga J, Oyama T, Nakagome I, Aoyama A, Sako K, Makishima M, Hirono S, Morikawa K, Hashimoto Y, Miyachi H. Yakugaku Zasshi. 2009 Jun; 129(6):709-18.
Phenoxyacetic acids as PPARδ partial agonists: synthesis, optimization, and in vivo efficacy. [Bioorg Med Chem Lett. 2011]
Phenoxyacetic acids as PPARδ partial agonists: synthesis, optimization, and in vivo efficacy.
Evans KA, Shearer BG, Wisnoski DD, Shi D, Sparks SM, Sternbach DD, Winegar DA, Billin AN, Britt C, Way JM, et al. Bioorg Med Chem Lett. 2011 Apr 15; 21(8):2345-50. Epub 2011 Mar 15.
Review PPARdelta in humans: genetic and pharmacological evidence for a significant metabolic function. [Curr Opin Lipidol. 2009]
Review PPARdelta in humans: genetic and pharmacological evidence for a significant metabolic function.
Karpe F, Ehrenborg EE. Curr Opin Lipidol. 2009 Aug; 20(4):333-6.

See reviews... See all...

Cited by 1 PubMed Central article

Regulation of tissue-specific carboxylesterase expression by pregnane x receptor and constitutive androstane receptor. [Drug Metab Dispos. 2009]
Regulation of tissue-specific carboxylesterase expression by pregnane x receptor and constitutive androstane receptor.
Xu C, Wang X, Staudinger JL. Drug Metab Dispos. 2009 Jul; 37(7):1539-47. Epub 2009 Apr 9.

Structures reported by this article

Ppardelta Complexed With An Anthranilic Acid Partial Agonist

PDB: 3DY6

Source: Homo sapiens

Method: X-Ray Diffraction

Resolution: 2.9 Å

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioAssay
PubChem BioAssay experiments on the biological activities of small molecules that cite the current articles. The depositors of BioAssay data provide these references.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Structure
Three-dimensional structure records in the NCBI Structure database for data reported in the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Discovery of a novel class of PPARdelta partial agonists.
Discovery of a novel class of PPARdelta partial agonists.
Bioorg Med Chem Lett. 2008 Sep 15 ;18(18):5018-22. Epub 2008 Aug 9 .

PubMed
Urbanization and the likelihood of a cesarean section.
Urbanization and the likelihood of a cesarean section.
Eur J Obstet Gynecol Reprod Biol. 2008 Dec ;141(2):104-10. Epub 2008 Aug 22 .

PubMed
Tadalafil administered once daily for lower urinary tract symptoms secondary to ...
Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a dose finding study.
J Urol. 2008 Oct ;180(4):1228-34. Epub 2008 Aug 22 .

PubMed
Degree of hyperinsulinemia, independent of androgen levels, is an important dete...
Degree of hyperinsulinemia, independent of androgen levels, is an important determinant of the severity of hirsutism in PCOS.
Fertil Steril. 2009 Aug ;92(2):643-7. Epub 2008 Aug 22 .

PubMed
Histone modifying enzymes: structures, mechanisms, and specificities.
Histone modifying enzymes: structures, mechanisms, and specificities.
Biochim Biophys Acta. 2009 Jan ;1789(1):58-68. Epub 2008 Aug 3 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Discovery of a novel class of PPARdelta partial agonists.

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Chemical Information

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Structures reported by this article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information