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    J Trauma Stress. 2008 Aug;21(4):417-20.

    Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin.

    Thompson CE, Taylor FB, McFall ME, Barnes RF, Raskind MA.

    VA Northwest Network, Mental Illness Research, Education and Clinical Center, Seattle, WA 98108, USA.

    Twenty-two veterans with posttraumatic stress disorder (PTSD) were assessed for trauma-related nightmares and nonnightmare distressed awakenings (NNDA) before and after treatment with the alpha-1 adrenoreceptor antagonist prazosin at an average bedtime dose of 9.6 mg/day. Ratings combining frequency and intensity dimensions of trauma-related nightmares decreased from 3.6 to 2.2, NNDA from 5.2 to 2.1, and sleep difficulty from 7.2 to 4.1 per week. These results suggest that increased brain adrenergic activity may contribute to the pathophysiology of both trauma-related nightmares and NNDA in PTSD.

    PMID: 18720392 [PubMed - indexed for MEDLINE]

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    • Prazosin (Minipress®)

      Prazosin is used alone or in combination with other medications to treat high blood pressure. Prazosin is in a class of medications called alpha-blockers. It works by relaxing the blood vessels so that blood can flow mor...

    • Source: AHFS Consumer Medication Information

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