Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Mol Cell Biol. 2008 Sep;9(9):673-8. doi: 10.1038/nrm2479.

Endogenous small interfering RNAs in animals.

Author information

  • 1Department of Developmental Biology, Sloan-Kettering Institute, 521 Rockefeller Research Laboratories, New York, New York 10065, USA.


Until recently, only nematodes among animals had a well-defined endogenous small interfering RNA (endo-siRNA) pathway. This has changed dramatically with the recent discovery of diverse intramolecular and intermolecular substrates that generate endo-siRNAs in Drosophila melanogaster and mice. These findings suggest broad and possibly conserved roles for endogenous RNA interference in regulating host-gene expression and transposable element transcripts. They also raise many questions regarding the biogenesis and function of small regulatory RNAs in animals.

[PubMed - indexed for MEDLINE]
Free PMC Article

Images from this publication.See all images (4)Free text

Figure 1
Figure 2
Figure 3
Figure 4
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk