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    Bioinformatics. 2008 Oct 15;24(20):2418-9. Epub 2008 Aug 20.

    cneViewer: a database of conserved non-coding elements for studies of tissue-specific gene regulation.

    Persampieri J, Ritter DI, Lees D, Lehoczky J, Li Q, Guo S, Chuang JH.

    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA.

    There are thousands of strongly conserved non-coding elements (CNEs) in vertebrate genomes, and their functions remain largely unknown. However, without biologically relevant criteria for prioritizing them, selecting a particular CNE sequences to study can be haphazard. To address this problem, we present cneViewer-a database and webtool that systematizes information on conserved non-coding DNA elements in zebrafish. A key feature here is the ability to search for CNEs that may be relevant to tissue-specific gene regulation, based on known developmental expression patterns of nearby genes. cneViewer provides this and other organizing features that significantly facilitate experimental design and CNE analysis.

    PMID: 18718943 [PubMed - indexed for MEDLINE]

    PMCID: 2562007

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