A 42-year-old man developed progressive scleral iatrogenic staphyloma in the region of a previous trabeculectomy with mitomycin C after three sessions of diode laser transscleral cyclophotocoagulation for a refractory glaucoma secondary to trauma. After clinical and laboratory evaluations, no signs of systemic or autoimmune disorders were found. The patient underwent a reinforcement of the eye wall with a scleral patch over the staphyloma area and a glaucoma drainage device was implanted. Repeated transscleral cyclophotocoagulation procedures should be performed cautiously in patients who have had previous trabeculectomy.