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Neuroepidemiology. 2008;31(3):139-49. doi: 10.1159/000151523. Epub 2008 Aug 21.

Environmental epidemiology of essential tremor.

Author information

  • 1GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. EDL2@columbia.edu

Abstract

BACKGROUND:

Essential tremor (ET) is one of the most common neurological disorders. Despite this, the disease mechanisms and etiology are not well understood. While susceptibility genotypes undoubtedly underlie many ET cases, no ET genes have been identified thus far. As with many other progressive, degenerative neurological disorders, it is likely that environmental factors contribute to the etiology of ET. Environmental epidemiology is the study in specific populations or communities of the effect on human health of physical, biologic and chemical factors in the external environment. The purpose of this article is to review current knowledge with regards to the environmental epidemiology of ET.

RESULTS:

As will be discussed, a series of preliminary case-control studies in recent years has begun to explore several candidate toxins/exposures, including harmane (1-methyl-9H-pyrido[3,4-b]indole), lead and agricultural exposures/pesticides.

CONCLUSIONS:

While several initial results are promising, as will be discussed, additional studies are needed to more definitively establish whether these exposures are associated with ET and if they are of etiological importance.

2008 S. Karger AG, Basel.

PMID:
18716411
[PubMed - indexed for MEDLINE]
PMCID:
PMC2683985
Free PMC Article
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