Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Clin Exp Immunol. 2008 Aug;153(2):162-73. doi: 10.1111/j.1365-2249.2008.03704.x.

Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease.

Author information

  • 1Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, London, UK. p.c.dubois@qmul.ac.uk

Abstract

Recent advances in immunological and genetic research in coeliac disease provide new and complementary insights into the immune response driving this chronic intestinal inflammatory disorder. Both approaches confirm the central importance of T cell-mediated immune responses to disease pathogenesis and have further begun to highlight other relevant components of the mucosal immune system, including innate immunity and the control of lymphocyte trafficking to the mucosa. In the last year, the first genome wide association study in celiac disease led to the identification of multiple new risk variants. These risk regions implicate genes involved in the immune system. Overlap with autoimmune diseases is striking with several of these regions being shown to confer susceptibility to other chronic immune-mediated diseases, particularly type 1 diabetes.

PMID:
18713140
[PubMed - indexed for MEDLINE]
PMCID:
PMC2492906
Free PMC Article

Images from this publication.See all images (3)Free text

Fig. 1
Fig. 2
Fig. 3
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Blackwell Publishing Icon for PubMed Central
    Loading ...
    Write to the Help Desk