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Pediatr Dev Pathol. 2008 Nov;11(6):421-3. doi: 10.2350/08-08-0511.1.

Morphology and etiology meet at the maternal-fetal interface.

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  • 1Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY, USA.


Molecular diagnostic testing is leaving its mark in many areas of medicine; no less in perinatal pathology. This CONTEXT article uses the finding of Gogia and Machin in this issue of Pediatric and Developmental Pathology that genetic or acquired thrombophilias are associated with fetal thrombotic vasculopathy, massive perivillous fibrin deposition, and maternal floor infarction as an example of how molecular testing is providing possible etiologies for entities that heretofore have largely been only morphologic diagnoses.

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