Methods Mol Biol. 2008;453:281-96.

Computational diagnostics with gene expression profiles.

Lottaz C, Kostka D, Markowetz F, Spang R.

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Max Planck Institute for Molecular Genetics and Berlin Center for Genome-Based Bioinformatics, Berlin, Germany.

Abstract

Gene expression profiling using micro-arrays is a modern approach for molecular diagnostics. In clinical micro-array studies, researchers aim to predict disease type, survival, or treatment response using gene expression profiles. In this process, they encounter a series of obstacles and pitfalls. This chapter reviews fundamental issues from machine learning and recommends a procedure for the computational aspects of a clinical micro-array study.

PMID:: 18712310; [PubMed - indexed for MEDLINE]

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Computational diagnostics with gene expression profiles.

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