In Vivo. 2008 Jul-Aug;22(4):441-5.

Review. Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer.

Source

David and Alice Jurist Institute for Medical Research, Hackensack University Medical Center Hackensack, NJ 07601, USA. bradlowhl@gmail.com

Abstract

Assessment of the oral use of indole-3-carbinol (I3C) as a chemoprotective compound has not sufficiently considered the chemical instability of I3C. This review addresses the question of whether I3C is directly active in its own right or only serves as a precursor, with all of the biological responses coming from reaction products arising in culture media and in the presence of stomach acid. Because of the rapid conversion of I3C into its dimer. diindolylmethane (DIM), and trimers very little circulating I3C is present following oral use to effect a biological response. Reports of toxicity associated with oral use of I3C relate to unfavorable enzyme induction, which can be attributed to non-DIM reaction products. Because DIM provides a predictable, safer response than the mélange of compounds derived from I3C DIM should be regarded as the chemoprotective compound of choice.

PMID:: 18712169; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

HighWire Press - PDF

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Related citations

Review The natural chemopreventive compound indole-3-carbinol: state of the science. [In Vivo. 2006]
Review The natural chemopreventive compound indole-3-carbinol: state of the science.
Rogan EG. In Vivo. 2006 Mar-Apr; 20(2):221-8.
Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium. [J Nutr. 2001]
Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium.
Chen DZ, Qi M, Auborn KJ, Carter TH. J Nutr. 2001 Dec; 131(12):3294-302.
3,3'-Diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancer. [Biochem Biophys Res Commun. 2006]
3,3'-Diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancer.
Garikapaty VP, Ashok BT, Tadi K, Mittelman A, Tiwari RK. Biochem Biophys Res Commun. 2006 Feb 10; 340(2):718-25. Epub 2005 Dec 20.
Diindolylmethane (DIM) spontaneously forms from indole-3-carbinol (I3C) during cell culture experiments. [In Vivo. 2010]
Diindolylmethane (DIM) spontaneously forms from indole-3-carbinol (I3C) during cell culture experiments.
Bradlow HL, Zeligs MA. In Vivo. 2010 Jul-Aug; 24(4):387-91.
Review Indole-3-carbinol and prostate cancer. [J Nutr. 2004]
Review Indole-3-carbinol and prostate cancer.
Sarkar FH, Li Y. J Nutr. 2004 Dec; 134(12 Suppl):3493S-3498S.

See reviews... See all...

Cited by 3 PubMed Central articles

Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation. [Mol Endocrinol. 2010]
Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation.
Hall JM, Barhoover MA, Kazmin D, McDonnell DP, Greenlee WF, Thomas RS. Mol Endocrinol. 2010 Feb; 24(2):359-69. Epub 2009 Dec 23.
Modulation of aflatoxin B1-mediated genotoxicity in primary cultures of human hepatocytes by diindolylmethane, curcumin, and xanthohumols. [Toxicol Sci. 2009]
Modulation of aflatoxin B1-mediated genotoxicity in primary cultures of human hepatocytes by diindolylmethane, curcumin, and xanthohumols.
Gross-Steinmeyer K, Stapleton PL, Tracy JH, Bammler TK, Strom SC, Buhler DR, Eaton DL. Toxicol Sci. 2009 Dec; 112(2):303-10. Epub 2009 Sep 21.
A controlled safety study of diindolylmethane in the immature rat model. [Laryngoscope. 2009]
A controlled safety study of diindolylmethane in the immature rat model.
Elackattu AP, Feng L, Wang Z. Laryngoscope. 2009 Sep; 119(9):1803-8.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Review. Indole-3-carbinol as a chemoprotective agent in breast and prostate canc...
Review. Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer.
In Vivo. 2008 Jul-Aug ;22(4):441-5.

PubMed
Immune evasion by adenovirus E3 proteins: exploitation of intracellular traffick...
Immune evasion by adenovirus E3 proteins: exploitation of intracellular trafficking pathways.
Curr Top Microbiol Immunol. 2004 ;273:29-85.

PubMed
Adenoviruses: update on structure and function.
Adenoviruses: update on structure and function.
J Gen Virol. 2009 Jan ;90(Pt 1):1-20.

PubMed
Tinea corporis, tinea cruris, tinea nigra, and piedra.
Tinea corporis, tinea cruris, tinea nigra, and piedra.
Dermatol Clin. 2003 Jul ;21(3):395-400, v.

PubMed
Large-scale analysis of the human and mouse transcriptomes.
Large-scale analysis of the human and mouse transcriptomes.
Proc Natl Acad Sci U S A. 2002 Apr 2 ;99(7):4465-70. Epub 2002 Mar 19 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: