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Nat Clin Pract Cardiovasc Med. 2008 Oct;5(10):621-35. doi: 10.1038/ncpcardio1322. Epub 2008 Aug 19.

The use of high-sensitivity assays for C-reactive protein in clinical practice.

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  • 1Johns Hopkins Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.


High-sensitivity assays that accurately measure levels of the inflammatory biomarker C-reactive protein have been proposed for use in assessments of risk for cardiovascular disease (CVD). A growing body of evidence supports recommendations for these tests in selected asymptomatic individuals deemed to be at intermediate risk of CVD according to traditional risk-factor assessments and who do not already warrant chronic treatment with aspirin and statin therapy. Data suggests that these high-sensitivity assays should be used in combination with measurements of LDL-cholesterol levels to assist risk stratification of selected patients for prevention of CVD.

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