Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

Nat Genet. 2008 Sep;40(9):1056-8. doi: 10.1038/ng.209.

Abstract

To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ankyrins / genetics*
  • Bipolar Disorder / genetics*
  • Calcium Channels, L-Type / genetics*
  • Chromosomes, Human, Pair 10
  • Chromosomes, Human, Pair 12
  • Chromosomes, Human, Pair 15
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study*
  • Humans
  • Logistic Models
  • Polymorphism, Single Nucleotide

Substances

  • ANK3 protein, human
  • Ankyrins
  • CACNA1C protein, human
  • Calcium Channels, L-Type