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Nat Biotechnol. 2008 Sep;26(9):1003-10. doi: 10.1038/nbt.1487.

Network-based prediction of human tissue-specific metabolism.

Author information

  • 1School of Computer Science, Tel-Aviv University, Tel-Aviv 69978, Israel. shlomito@post.tau.ac.il

Abstract

Direct in vivo investigation of mammalian metabolism is complicated by the distinct metabolic functions of different tissues. We present a computational method that successfully describes the tissue specificity of human metabolism on a large scale. By integrating tissue-specific gene- and protein-expression data with an existing comprehensive reconstruction of the global human metabolic network, we predict tissue-specific metabolic activity in ten human tissues. This reveals a central role for post-transcriptional regulation in shaping tissue-specific metabolic activity profiles. The predicted tissue specificity of genes responsible for metabolic diseases and tissue-specific differences in metabolite exchange with biofluids extend markedly beyond tissue-specific differences manifest in enzyme-expression data, and are validated by large-scale mining of tissue-specificity data. Our results establish a computational basis for the genome-wide study of normal and abnormal human metabolism in a tissue-specific manner.

PMID:
18711341
[PubMed - indexed for MEDLINE]
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