Rinsho Ketsueki. 2008 Jul;49(7):516-20.

[Evans syndrome associated with idiopathic mixed-type autoimmune hemolytic anemia].

[Article in Japanese]

Kakinoki Y, Nagase M, Okada K, Chiba K, Fukuhara T, Miyake T.

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Division of Hematology/Oncology, Department of Internal Medicine, Asahikawa City Hospital.

Abstract

A 60-year-old man was admitted to our hospital with severe anemia and blood findings showed hemolytic anemia. Further serological examination revealed both warm-reactive autoantibody and cold agglutinin against erythrocytes. The cold agglutinin showed a low titer, 1 : 32 at 4 degrees C, and had a high thermal amplitude of 30 degrees C or higher, resulting in sufficient activity for hemolysis. Since no underlying disorders could be detected, the diagnosis was idiopathic mixed-type autoimmune hemolytic anemia. Although thrombocytopenia (Evans syndrome) subsequently appeared, corticosteroid was extremely effective for both anemia and thrombocytopenia. In this report we describe a rare case of Evans syndrome associated with mixed-type autoimmune hemolytic anemia, which had a dramatic response to corticosteroid therapy.

PMID:: 18709985; [PubMed - indexed for MEDLINE]

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[Evans syndrome associated with idiopathic mixed-type autoimmune hemolytic anemia].

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