Psychiatry Res. 2008 Oct 30;164(1):73-6. Epub 2008 Aug 15.

The MAO-A genotype does not modulate resting brain metabolism in adults.

Alia-Klein N, Kriplani A, Pradhan K, Ma JY, Logan J, Williams B, Craig IW, Telang F, Tomasi D, Goldstein RZ, Wang GJ, Volkow ND, Fowler JS.

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Medical Department, Brookhaven National Laboratory, Upton, New York 11973, United States. nellyklein@bnl.gov

Abstract

Variation in the monoamine-oxidase-A (MAO-A) gene has been associated with volumetric changes in corticolimbic regions with differences in their response to relevant emotional tasks. Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype.

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PMCID:: PMC2596889

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