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    Psychiatry Res. 2008 Oct 30;164(1):73-6. Epub 2008 Aug 15.

    The MAO-A genotype does not modulate resting brain metabolism in adults.

    Alia-Klein N, Kriplani A, Pradhan K, Ma JY, Logan J, Williams B, Craig IW, Telang F, Tomasi D, Goldstein RZ, Wang GJ, Volkow ND, Fowler JS.

    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, United States. nellyklein@bnl.gov

    Variation in the monoamine-oxidase-A (MAO-A) gene has been associated with volumetric changes in corticolimbic regions with differences in their response to relevant emotional tasks. Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype.

    PMID: 18706791 [PubMed - indexed for MEDLINE]

    PMCID: 2596889

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