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Genes Dev. 2008 Sep 1;22(17):2353-8. doi: 10.1101/gad.1681808. Epub 2008 Aug 14.

TBP, Mot1, and NC2 establish a regulatory circuit that controls DPE-dependent versus TATA-dependent transcription.

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  • 1Section of Molecular Biology, University of California at San Diego, La Jolla, California 92093, USA.

Abstract

The RNA polymerase II core promoter is a structurally and functionally diverse transcriptional module. RNAi depletion and overexpression experiments revealed a genetic circuit that controls the balance of transcription from two core promoter motifs, the TATA box and the downstream core promoter element (DPE). In this circuit, TBP activates TATA-dependent transcription and represses DPE-dependent transcription, whereas Mot1 and NC2 block TBP function and thus repress TATA-dependent transcription and activate DPE-dependent transcription. This regulatory circuit is likely to be one means by which biological networks can transmit transcriptional signals, such as those from DPE-specific and TATA-specific enhancers, via distinct pathways.

PMID:
18703680
[PubMed - indexed for MEDLINE]
PMCID:
PMC2532932
Free PMC Article

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