Bioinformatics. 2008 Oct 15;24(20):2277-80. Epub 2008 Aug 14.

A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes.

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MRC Centre for Protein Engineering, Cambridge, UK. tony@mrc-lmb.cam.ac.uk

Abstract

We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one ratio. Based on the conserved sequence features we predict that this domain may function as a RNA recognition and binding module.

PMID:: 18703587; [PubMed - indexed for MEDLINE]
PMCID:: PMC2562017

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