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Genomics. 2008 Nov;92(5):255-64. doi: 10.1016/j.ygeno.2008.07.001. Epub 2008 Aug 24.

Applications of next-generation sequencing technologies in functional genomics.

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  • 1BC Cancer Agency Genome Sciences Centre, Vancouver, BC, Canada.


A new generation of sequencing technologies, from Illumina/Solexa, ABI/SOLiD, 454/Roche, and Helicos, has provided unprecedented opportunities for high-throughput functional genomic research. To date, these technologies have been applied in a variety of contexts, including whole-genome sequencing, targeted resequencing, discovery of transcription factor binding sites, and noncoding RNA expression profiling. This review discusses applications of next-generation sequencing technologies in functional genomics research and highlights the transforming potential these technologies offer.

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