Abstract
The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.
MeSH terms
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism
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Gene Products, tax / chemistry
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Gene Products, tax / genetics
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Gene Products, tax / metabolism*
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HTLV-I Infections / metabolism*
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HTLV-I Infections / physiopathology
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HTLV-I Infections / virology
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Host-Pathogen Interactions*
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Human T-lymphotropic virus 1 / chemistry
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Human T-lymphotropic virus 1 / enzymology*
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Human T-lymphotropic virus 1 / genetics
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Humans
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Nuclear Pore Complex Proteins / genetics
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Nuclear Pore Complex Proteins / metabolism
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Protein Binding
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Protein Structure, Tertiary
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Signal Transduction
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Transcription Factors / genetics
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Transcription Factors / metabolism
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Transcriptional Activation
Substances
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Cell Cycle Proteins
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Gene Products, tax
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Nuclear Pore Complex Proteins
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Transcription Factors