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Nano Lett. 2008 Sep;8(9):2993-7. doi: 10.1021/nl802059m. Epub 2008 Aug 14.

"Chemical transformers" from nanoparticle ensembles operated with logic.

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  • 1Department of Chemistry and Biomolecular Science and NanoBio Laboratory, Clarkson University, Potsdam, New York 13699-5810, USA.


The pH-responsive nanoparticles were coupled with information-processing enzyme-based systems to yield "smart" signal-responsive hybrid systems with built-in Boolean logic. The enzyme systems performed AND/OR logic operations, transducing biochemical input signals into reversible structural changes (signal-directed self-assembly) of the nanoparticle assemblies, thus resulting in the processing and amplification of the biochemical signals. The hybrid system mimics biological systems in effective processing of complex biochemical information, resulting in reversible changes of the self-assembled structures of the nanoparticles. The bioinspired approach to the nanostructured morphing materials could be used in future self-assembled molecular robotic systems.

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