Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Br J Psychiatry. 2008 Jul;193(1):10-7. doi: 10.1192/bjp.bp.106.031088.

Efficacy of antidepressants in juvenile depression: meta-analysis.

Author information

  • 1MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK. e.tsapakis@iop.kcl.ac.uk

Erratum in

  • Br J Psychiatry. 2008 Oct;193(4):346.
  • Br J Psychiatry. 2008 Aug;193(2):169.

Abstract

BACKGROUND:

The safety of antidepressants in children and adolescents is being questioned and the efficacy of these drugs in juvenile depression remains uncertain.

AIMS:

To assess antidepressant efficacy in juvenile depression.

METHOD:

Systematic review and meta-analysis of randomised controlled trials (RCTs) comparing responses to antidepressants, overall and by type, v. placebo in young people with depression.

RESULTS:

Thirty drug-placebo contrasts in RCTs lasting 8 weeks (median) involved 3069 participants (512 person-years) of average age 13.5 years. Meta-analysis yielded a modest pooled drug/placebo response rate ratio (RR=1.22, 95% CI 1.15-1.31), with little separation between antidepressant types. Findings were similar for response rate differences and corresponding number needed to treat (NNT): overall NNT=9; tricyclic antidepressants NNT=14 > serotonin reuptake inhibitors NNT=9 > other antidepressants NNT=8. Numbers needed to treat decreased with increasing age: children (NNT=21) > mixed ages (NNT=10) > adolescents (NNT=8).

CONCLUSIONS:

Antidepressants of all types showed limited efficacy in juvenile depression, but fluoxetine might be more effective, especially in adolescents. Studies in children and in severely depressed, hospitalised or suicidal juvenile patients are needed, and effective, safe and readily accessible treatments for juvenile depression are urgently required.

Comment in

PMID:
18700212
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Health
    Loading ...
    Write to the Help Desk