World J Gastroenterol. 2008 Aug 7;14(29):4697-700.

Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus.

Okan G, Yaylaci S, Peker O, Kaymakoglu S, Saruc M.

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Gastroenterohepatology Department, Acibadem Bakirkoy Hospital, Istanbul, Turkey.

Abstract

Stevens-Johnson syndrome (SJS) is a serious and potentially life-threatening disease. Vanishing bile duct syndrome (VBDS) is a rare cause of progressive cholestasis. Both syndromes are mostly related with drugs. We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature. It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus. This case reminds physicians of the importance of drug reactions, their severity, techniques for diagnosis and methods of management.

PMID:: 18698687; [PubMed - indexed for MEDLINE]
PMCID:: PMC2738797

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