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Physiology (Bethesda). 2008 Aug;23:194-204. doi: 10.1152/physiol.00009.2008.

Presenilins: members of the gamma-secretase quartets, but part-time soloists too.

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  • 1Department for Developmental and Molecular Genetics, VIB, Leuven.


The presenilins in combination with other proteins generate different gamma-secretases, which are involved in the regulated intramembrane proteolysis of a variety of proteins. Understanding the specificity and regulation of these proteases will potentially lead to novel therapeutics for Alzheimer's disease and cancer. Presenilins appear also to exert additional functions outside of the gamma-secretase quartets, which needs further investigation.

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