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Neurocrit Care. 2009;10(1):103-15. doi: 10.1007/s12028-008-9133-4. Epub 2008 Aug 12.

Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit.

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  • 1Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Abstract

Calcium plays a central role in neuronal function and injury. Dantrolene, an inhibitor of the ryanodine receptor, inhibits intracellular calcium release from the sarco-endoplasmic reticulum. We review the available data of dantrolene as a potential neuroprotective agent and briefly summarize its other pharmacologic effects that may have potential applications for patients in the neurointensive care unit (NICU). Areas with the need for continued research are identified.

PMID:
18696266
[PubMed - indexed for MEDLINE]
PMCID:
PMC2702250
Free PMC Article
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