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Diabetologia. 2008 Oct;51(10):1757-60. doi: 10.1007/s00125-008-1114-9. Epub 2008 Aug 12.

A genetic link between type 2 diabetes and prostate cancer.

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  • 1Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Magdalen Road, Exeter, UK. Tim.frayling@pms.ac.uk

Abstract

Epidemiological studies suggest that men with type 2 diabetes are less likely than non-diabetic men to develop prostate cancer. The cause of this association is not known. Recent genetic studies have highlighted a potential genetic link between the two diseases. Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. Other, separate, studies have identified different variants in the JAZF1 gene, one associated with type 2 diabetes, another associated with prostate cancer. These findings are unlikely to completely explain the epidemiological association between the two diseases but they provide new insight into a possible direct causal link, rather than one that is confounded or biased in some way.

PMID:
18696045
[PubMed - indexed for MEDLINE]
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