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Indian Pediatr. 2008 Jul;45(7):559-63.

Outcome in West syndrome.

Author information

  • 1Department of Pediatric Neurology, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India. drnutties2000@yahoo.co.in

Abstract

OBJECTIVES:

To assess the seizure and developmental outcome in children with West syndrome with respect to treatment lag.

METHODS:

Twenty-six children satisfying inclusion criteria of West syndrome i.e., infantile spasms, psychomotor retardation and abnormal EEG pattern were prospectively evaluated. Response to treatment was assessed based on seizure control, EEG, developmental assessment and parental observations.

RESULTS:

The time lag from onset of seizures to appropriate treatment was <1 month in 11 children; 1-6 months in 8 children; and >6 months in 7 children. Children with treatment lag <1 month fared better than those who had a large treatment lag (P<0.05). Children with good seizure control also showed better developmental improvement (P<0.05).

CONCLUSION:

Children with West syndrome have better seizure control and development, if the treatment is started within 1 month of onset of symptoms.

PMID:
18695274
[PubMed - indexed for MEDLINE]
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