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J Biol Chem. 2008 Nov 28;283(48):33021-5. doi: 10.1074/jbc.R800012200. Epub 2008 Aug 11.

Endocannabinoids and the control of energy homeostasis.

Author information

  • 1Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-9413, USA. gkunos@mail.nih.gov

Abstract

Endocannabinoids (ECBs) are ubiquitous lipid mediators that act through the same G protein-coupled receptors (CB1 and CB2) that recognize plant-derived cannabinoids. As regulators of metabolism, ECBs are anabolic: they increase the intake, promote the storage, and decrease the expenditure of energy. Recent work indicates that activation of peripheral CB1 receptors by ECBs plays a key role in the hormonal/metabolic changes associated with obesity/metabolic syndrome and may be targeted for its pharmacotherapy.

PMID:
18694938
[PubMed - indexed for MEDLINE]
PMCID:
PMC2586261
Free PMC Article

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