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Fungal Genet Biol. 2009 Mar;46 Suppl 1:S62-71. doi: 10.1016/j.fgb.2008.07.009. Epub 2008 Jul 24.

Proteins involved in microbody biogenesis and degradation in Aspergillus nidulans.

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  • 1Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, PO Box 14, NL-9750 AA Haren, The Netherlands.


Fungal microbodies (peroxisomes) are inducible organelles that proliferate in response to nutritional cues. Proteins involved in peroxisome biogenesis/proliferation are designated peroxins and are encoded by PEX genes. An autophagy-related process, termed pexophagy, is responsible for the selective removal of peroxisomes from the cell. Several genes involved in pexophagy are also required for autophagy and are collectively known as ATG genes. We have re-analysed the Aspergillus nidulans genome for the presence of PEX and ATG genes and have identified a number of previously missed genes. Also, we manually determined the correct intron positions in each identified gene. The data show that in A. nidulans and related fungi the basic set of genes involved in peroxisome biogenesis or degradation are conserved. However, both processes have features that more closely resemble organelle formation/degradation in mammals rather than yeast. Thus, filamentous fungi like A. nidulans are ideal model systems for peroxisome homeostasis in man.

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