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Biochem Biophys Res Commun. 2008 Oct 17;375(2):194-9. doi: 10.1016/j.bbrc.2008.07.152. Epub 2008 Aug 9.

The actin propulsive machinery: the proteome of Listeria monocytogenes tails.

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  • 1Department of Medical Protein Research, VIB, B-9000 Ghent, Belgium.


Actin-based comet tails produced by Listeria monocytogenes are considered as representative models for cellular force-producing machineries crucial for cell migration. We here present a proteomic picture of these tails formed in extracts from brain and platelets. This provides a comprehensive view, revealing high molecular complexity and novel host cell proteins as tail components, and suggests the participation of specific multicomponent regulatory complexes. This work forms a new basis to expand current models of cellular protrusion.

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