Paediatr Respir Rev. 2008 Sep;9(3):168-74; quiz 174-5. Epub 2008 Jul 29.

Role of high-resolution computed tomography in the detection of early cystic fibrosis lung disease.

Linnane B, Robinson P, Ranganathan S, Stick S, Murray C.

Source

Department of Respiratory Medicine, Royal Children's Hospital, Melbourne, Australia. barry.linnane@rch.org.au

Abstract

High-resolution computed tomography (HRCT) has been demonstrated to be sensitive at detecting early lung disease in cystic fibrosis (CF), often before it is apparent clinically. There is emerging evidence that structural changes in the lung occur earlier in life than previously appreciated. Despite this, the role of HRCT in young children with CF has yet to be defined, principally because the repeated exposure of children to X-ray doses several multiples that of a standard chest X-ray raises the concern of the long-term risks of ionizing radiation. With the challenges of acquiring HRCT images in young children in mind, we review scanning protocols and settings specific to young children, and review the best available evidence that describes early structural lung disease in young children with CF. The role of CT scoring and quantitative measures of CF lung disease are reviewed. The challenge for the future is to develop techniques that provide clinically useful information at the lowest possible radiation risk.

PMID:: 18694708; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Save items

Related citations in PubMed

Review High-resolution CT scanning: potential outcome measure. [Curr Opin Pulm Med. 2004]
Review High-resolution CT scanning: potential outcome measure.
Robinson TE. Curr Opin Pulm Med. 2004 Nov; 10(6):537-41.
Progressive damage on high resolution computed tomography despite stable lung function in cystic fibrosis. [Eur Respir J. 2004]
Progressive damage on high resolution computed tomography despite stable lung function in cystic fibrosis.
de Jong PA, Nakano Y, Lequin MH, Mayo JR, Woods R, Paré PD, Tiddens HA. Eur Respir J. 2004 Jan; 23(1):93-7.
Cystic fibrosis: when should high-resolution computed tomography of the chest Be obtained? [Pediatrics. 1998]
Cystic fibrosis: when should high-resolution computed tomography of the chest Be obtained?
Santamaria F, Grillo G, Guidi G, Rotondo A, Raia V, de Ritis G, Sarnelli P, Caterino M, Greco L. Pediatrics. 1998 May; 101(5):908-13.
Review High-resolution computed tomography (HRCT) should not be considered as a routine assessment method in cystic fibrosis lung disease. [Paediatr Respir Rev. 2006]
Review High-resolution computed tomography (HRCT) should not be considered as a routine assessment method in cystic fibrosis lung disease.
Cooper P, MacLean J. Paediatr Respir Rev. 2006 Sep; 7(3):197-201. Epub 2006 Aug 4.
Review Primary graft dysfunction; possible evaluation by high resolution computed tomography, and suggestions for a scoring system. [Interact Cardiovasc Thorac Sur...]
Review Primary graft dysfunction; possible evaluation by high resolution computed tomography, and suggestions for a scoring system.
Belmaati E, Jensen C, Kofoed KF, Iversen M, Steffensen I, Nielsen MB. Interact Cardiovasc Thorac Surg. 2009 Nov; 9(5):859-67. Epub 2009 Aug 11.

See reviews... See all...

Cited by 2 PubMed Central articles

Air trapping on chest CT is associated with worse ventilation distribution in infants with cystic fibrosis diagnosed following newborn screening. [PLoS One. 2011]
Air trapping on chest CT is associated with worse ventilation distribution in infants with cystic fibrosis diagnosed following newborn screening.
Hall GL, Logie KM, Parsons F, Schulzke SM, Nolan G, Murray C, Ranganathan S, Robinson P, Sly PD, Stick SM, et al. PLoS One. 2011; 6(8):e23932. Epub 2011 Aug 19.
A new scoring system in Cystic Fibrosis: statistical tools for database analysis - a preliminary report. [BMC Med Inform Decis Mak. 2008]
A new scoring system in Cystic Fibrosis: statistical tools for database analysis - a preliminary report.
Hafen GM, Hurst C, Yearwood J, Smith J, Dzalilov Z, Robinson PJ. BMC Med Inform Decis Mak. 2008 Oct 5; 8:44. Epub 2008 Oct 5.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Role of high-resolution computed tomography in the detection of early cystic fib...
Role of high-resolution computed tomography in the detection of early cystic fibrosis lung disease.
Paediatr Respir Rev. 2008 Sep ;9(3):168-74; quiz 174-5. Epub 2008 Jul 29 .

PubMed
A new scalp formulation of calcipotriene plus betamethasone compared with its ac...
A new scalp formulation of calcipotriene plus betamethasone compared with its active ingredients and the vehicle in the treatment of scalp psoriasis: a randomized, double-blind, controlled trial.
J Am Acad Dermatol. 2008 Sep ;59(3):455-63.

PubMed
Potent CCR4 antagonists: synthesis, evaluation, and docking study of 2,4-diamino...
Potent CCR4 antagonists: synthesis, evaluation, and docking study of 2,4-diaminoquinazolines.
Bioorg Med Chem. 2008 Sep 1 ;16(17):7968-74. Epub 2008 Jul 29 .

PubMed
The complexity of symptoms and problems experienced in children with cancer: a r...
The complexity of symptoms and problems experienced in children with cancer: a review of the literature.
J Pain Symptom Manage. 2009 Mar ;37(3):403-18. Epub 2008 Aug 9 .

PubMed
Influence of climatic variables on acute myocardial infarction hospital admissio...
Influence of climatic variables on acute myocardial infarction hospital admissions.
Int J Cardiol. 2009 Oct 2 ;137(2):123-9. Epub 2008 Aug 9 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: