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1: Dev Cell. 2008 Aug;15(2):178-9.Click here to read Links

VEGFR3: a new target for antiangiogenesis therapy?

Padera TP, Jain RK.

Edwin L. Steele Laboratory of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

VEGFR-3 signaling plays an important role in developmental, physiological, and pathological angiogenesis and lymphangiogenesis. Tammela et al. in Nature show that VEGFR-3, via Notch regulation, is present on endothelial tip cells and is critical to sprouting angiogenesis.

PMID: 18694556 [PubMed - indexed for MEDLINE]