Expert Opin Biol Ther. 2008 Sep;8(9):1319-35.

In vivo gene transfer to the CNS using recombinant SV40-derived vectors.

Louboutin JP, Agrawal L, Liu B, Strayer DS.

Source

Thomas Jefferson University, Department of Pathology, Anatomy and Cell Biology, 1020 Locust Street, Room 255, Philadelphia, PA 19107, USA. jplouboutin@hotmail.com

Abstract

BACKGROUND:

Gene transfer to the CNS has been approached using various vectors.

OBJECTIVE:

We illustrate how SV40-derived vectors may be useful to deliver long-term gene expression to the brain, locally or diffusely.

RESULTS/CONCLUSION:

SV40-derived vectors transduce neurons and microglial cells. The potential utility of both localized and widespread gene delivery in treating neuroAIDS and other CNS diseases characterized by excessive oxidative stress is demonstrated. Finally, direct injection of rSV40 vectors into rat femoral bone marrow (BM) led to transgene expression in CNS neurons and microglia, mostly in the dentate gyrus and in the periventricular subependymal zone, suggesting that BM-derived cells may be progenitors of some CNS cells in adult animals, and that gene delivery to BM may allow transgene expression in newly formed neurons.

PMID:: 18694352; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Strategies for CNS-directed gene delivery: in vivo gene transfer to the brain using SV40-derived vectors. [Gene Ther. 2007]
Strategies for CNS-directed gene delivery: in vivo gene transfer to the brain using SV40-derived vectors.
Louboutin JP, Reyes BA, Agrawal L, Van Bockstaele E, Strayer DS. Gene Ther. 2007 Jun; 14(12):939-49. Epub 2007 Apr 19.
Protecting neurons from HIV-1 gp120-induced oxidant stress using both localized intracerebral and generalized intraventricular administration of antioxidant enzymes delivered by SV40-derived vectors. [Gene Ther. 2007]
Protecting neurons from HIV-1 gp120-induced oxidant stress using both localized intracerebral and generalized intraventricular administration of antioxidant enzymes delivered by SV40-derived vectors.
Louboutin JP, Agrawal L, Reyes BA, Van Bockstaele EJ, Strayer DS. Gene Ther. 2007 Dec; 14(23):1650-61. Epub 2007 Oct 4.
Gene transfer to the rhesus monkey brain using SV40-derived vectors is durable and safe. [Gene Ther. 2011]
Gene transfer to the rhesus monkey brain using SV40-derived vectors is durable and safe.
Louboutin JP, Marusich E, Fisher-Perkins J, Dufour JP, Bunnell BA, Strayer DS. Gene Ther. 2011 Jul; 18(7):682-91. Epub 2011 Mar 3.
Review Long-term gene expression in dividing and nondividing cells using SV40-derived vectors. [Mol Biotechnol. 2006]
Review Long-term gene expression in dividing and nondividing cells using SV40-derived vectors.
Strayer DS, Agrawal L, Cordelier P, Liu B, Louboutin JP, Marusich E, McKee HJ, Ren CN, Strayer MS. Mol Biotechnol. 2006 Oct; 34(2):257-70.
Review Simian virus-40 as a gene therapy vector. [DNA Cell Biol. 2004]
Review Simian virus-40 as a gene therapy vector.
Vera M, Fortes P. DNA Cell Biol. 2004 May; 23(5):271-82.

See reviews... See all...

Recent activity

Clear Turn Off Turn On

In vivo gene transfer to the CNS using recombinant SV40-derived vectors.
In vivo gene transfer to the CNS using recombinant SV40-derived vectors.
Expert Opin Biol Ther. 2008 Sep ;8(9):1319-35.

PubMed
Editorial commentary: antibiotics for treatment of acute respiratory tract infec...
Editorial commentary: antibiotics for treatment of acute respiratory tract infections: decreasing benefit, increasing risk, and the irrelevance of antimicrobial resistance.
Clin Infect Dis. 2008 Sep 15 ;47(6):744-6.

PubMed
Positive changes in bone marrow-derived cells in response to culture on an align...
Positive changes in bone marrow-derived cells in response to culture on an aligned bioscaffold.
Tissue Eng Part A. 2008 Sep ;14(9):1489-95.

PubMed
Functionalized mesoporous silica nanoparticle-based drug delivery system to resc...
Functionalized mesoporous silica nanoparticle-based drug delivery system to rescue acrolein-mediated cell death.
Nanomedicine (Lond). 2008 Aug ;3(4):507-19.

PubMed
Prioritizing Disease Genes by Analysis of Common Elements (PDG-ACE).
Prioritizing Disease Genes by Analysis of Common Elements (PDG-ACE).
AMIA Annu Symp Proc. 2007 Oct 11 :1068.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: