AMIA Annu Symp Proc. 2007 Oct 11:1068.

Prioritizing Disease Genes by Analysis of Common Elements (PDG-ACE).

McEachin RC, Keller BJ, Zandi PP, Almani M, McInnis MG.

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University of Mich., Ann Arbor, MI, USA.

Abstract

Complex diseases are characterized by multiple genetic and environmental influences on disease susceptibility. Since the multiple genetic influences converge on a single phenotype, some commonality may be evident among genes that influence the disease. We exploit this potential commonality among candidate disease genes to prioritize genes for further analysis and to pose novel, statistically significant, biologically plausible hypotheses on disease etiology.

PMID:: 18694166; [PubMed - indexed for MEDLINE]

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