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1: Clin Biochem. 2008 Oct;41(14-15):1162-7. Epub 2008 Jul 26.Click here to read Links

An oxidative stress score as a combined measure of the pro-oxidant and anti-oxidant counterparts in patients with coronary artery disease.

Vassalle C, Pratali L, Boni C, Mercuri A, Ndreu R.

G. Monasterio Foundation and Institute of Clinical Physiology, CNR, Pisa, Italy. cristina.vassalle@ifc.cnr.it

Oxidative stress plays a key role in the pathogenesis and development of atherosclerosis. AIM: To evaluate the relationship between a novel oxidative stress index (reflecting both oxidative and anti-oxidant counterparts) with traditional cardiovascular risk factors and C-reactive protein (CRP) in coronary artery disease (CAD). METHODS: 100 angiographically proven CAD and 70 control subjects (mean age: 65+/-10 years, 110 males), underwent a global cardiovascular risk assessment and serum CRP and oxidative stress estimation. The Oxidative-INDEX was calculated after automated evaluation of serum hydroperoxides and total anti-oxidant capacity (D-ROM and OXY-adsorbent Test, Diacron, Italy) subtracting the OXY standardized variable from the ROM standardized variable. RESULTS: The Oxidative-INDEX was higher in CAD with respect to control subjects (p < 0.001). A stepwise elevation in the Oxidative-INDEX levels was found depending on the number of affected vessels (p < 0.001). Oxidative stress was elevated according to the presence of diabetes (p < 0.001), smoking habit (p < 0.01), and hypercholesterolemia (p < 0.05). Oxidative-INDEX significantly correlated with aging (p < or = 0.05) and CRP (p < 0.001). The Oxidative-INDEX increased with the number of cardiovascular risk factors (p < 0.001). After adjustment for traditional CV risk factors, the multivariate logistic regression analysis indicated the Oxidative-INDEX concentration as an independent factor for CAD (odds ratio=1.4, confidence intervals=1.1-1.9, p < 0.05). CONCLUSION: Oxidative stress represents a shared molecular pathway in atherosclerotic-related conditions, and its estimation by the automated Oxidative-INDEX could represent a valuable tool and a promising target in the prevention, diagnosis and treatment of CAD in the clinical setting.

PMID: 18692492 [PubMed - indexed for MEDLINE]