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Int J Radiat Oncol Biol Phys. 2009 Jan 1;73(1):24-9. doi: 10.1016/j.ijrobp.2008.04.031. Epub 2008 Aug 7.

Effect of family history on outcomes in patients treated with definitive brachytherapy for clinically localized prostate cancer.

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  • 1Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY, USA.

Abstract

PURPOSE:

To determine the impact familial prostate cancer has on prognosis in men treated with brachytherapy for clinically localized prostate cancer.

METHODS AND MATERIALS:

A total of 1,738 consecutive patients with prostate cancer (cT1-3, N0/X, M0) received low-dose-rate brachytherapy alone or in combination with external beam radiation therapy or hormone ablation from 1992 to 2005. The primary end-point was freedom from biochemical failure (FFBF) using the Phoenix definition. Minimum follow-up was 2 years and the median follow-up was 60 months (range, 24-197 months).

RESULTS:

A total of 187 of 1,738 men (11%) had a family history of prostate cancer in a first-degree relative. For the low-risk patients, both groups had similar actuarial 5-year FFBF (97.2% vs. 95.5%, p = 0.516). For intermediate-risk patients, there was a trend toward improved biochemical control in men positive for family history (5-yr FFBF 100% vs. 93.6%, p = 0.076). For the high-risk patients, men with a positive family history had similar 5-year FFBF (92.8% vs. 85.2%, p = 0.124). On multivariate analysis, family history was not significant; use of hormones, high biologic effective dose, initial prostate-specific antigen value, and Gleason score were the significant variables predicting biochemical control.

CONCLUSIONS:

This is the first study to examine the relationship of familial prostate cancer and outcomed in men treated with brachytherapy alone or in combination therapy. Men with a positive family history have clinicopathologic characteristics and biochemical outcomes similar to those with sporadic disease.

PMID:
18692325
[PubMed - indexed for MEDLINE]
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