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Nucleic Acids Res. 2008 Sep;36(16):5335-49. doi: 10.1093/nar/gkn504. Epub 2008 Aug 9.

N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis.

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  • 1Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, Biotechnology Center, Department of Immunology, The Fourth Military Medical University, Xi'an, 710032, China.

Abstract

The tumor suppressor, p53, is a transcription factor which can modulate the transcription of a number of target genes that are involved in cell-cycle arrest and apoptosis. However, the apoptotic pathway mediated by p53 is not fully understood. Here, we showed that N-Myc downstream-regulated gene 2 (NDRG2) is a new target gene that is regulated by p53. NDRG2 mRNA and protein levels can be upregulated in a p53-dependent manner. The first intron of the NDRG2 gene contains a site that binds p53 directly and mediates wild-type p53-dependent transactivation. In addition, silencing of NDRG2 attenuates p53-mediated apoptosis, whereas overexpression of NDRG2 suppresses tumor cell growth, regardless of the presence or absence of p53. Our results indicate that NDRG2 is a novel p53-inducible target that is involved in the p53-mediated apoptosis pathway.

PMID:
18689861
[PubMed - indexed for MEDLINE]
PMCID:
PMC2532733
Free PMC Article
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