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J Am Coll Nutr. 2008 Apr;27(2):274-9.

Body size and serum 25 hydroxy vitamin D response to oral supplements in healthy older adults.

Author information

  • 1Bone Metabolism Laboratory, Jean Mayer USDA, HNRC on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA.

Abstract

BACKGROUND:

Vitamin D insufficiency is prevalent in the northeast United States. Since vitamin D insufficiency is readily amenable to supplementation, it is important to understand what factors are associated with serum 25 hydroxy vitamin D (25(OH)D) response to vitamin D supplementation.

OBJECTIVE:

In this study we examined the association of serum 25(OH)D response to vitamin D supplementation with body size in a population of elderly subjects.

METHODS:

257 healthy, ambulatory men and women 65 years of age or older were randomly assigned to treatment with either 700 IU/day (17.5 microg/d) of supplemental vitamin D(3) and 500 mg/day (12.5 mmol/d) of supplemental calcium, or to placebo.

RESULTS:

In multivariate regression analyses, after adjusting for baseline 25(OH)D, season, and sex, we found change in 25(OH)D to be inversely associated with baseline BMI (p = 0.01) in subjects treated with supplements for one year. Change in 25(OH)D was also negatively associated with other baseline anthropometric measurements in these subjects.

CONCLUSION:

Our study implies that body size should be taken into account when estimating the amount of vitamin D intake needed to raise 25(OH)D to the desired level.

PMID:
18689559
PMCID:
PMC2729752
[PubMed - indexed for MEDLINE]
Free PMC Article
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